Zuckerkandl and Pauling showed 50 years ago that molecular sequences are ‘documents of evolutionary history’. The composition of the molecular sequences of organisms living today has been passed on from ancestors from long ago. Unused segments get lost, new parts are added and small changes occur because replication is not error free. Whatever modifications have happened, they will have left traces in the molecular sequences.
In the advent of next generation sequencing technologies we have thousands of genomes available, however, we lack methods for genome-wide molecular dating. In this project, we will develop novel methods which will model not only mutations but also processes such as gene duplication, loss and transfer. We will also consider variation within species and devise methods that allow to use the genome-wide DNA sequences of multiple individuals per species to perform molecular dating.
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Vetmeduni Open Day: Do you get my drift?
Dr Rui Borges explains evolutionary processes with M&MsR
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Mathematical and Statistical Aspects of Molecular Biology (MASAMB 2019) – Asger and Gergely win prizes
We attended MASAMB 2019 and a project group meeting at the European Bioinformatics Institute in Cambridge last week, and were quiet succesful with Asger Hobolth winning “Best Senior Talk” and Gergely Szollosi wining to organize the next MASAMB 2020. See you in Hungary next year!
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Baboon paper get mentioning Standard
Standard and APA published an article about contribution to the Baboon project https://www.derstandard.de/story/2000097256225/einer-oder-sechs-wie-der-pavian-einzuschaetzen-ist https://science.apa.at/site/medizin_und_biotech/detail?key=SCI_20190131_SCI45051703646666088 There is also a press release in English Baboon genomes shed new light on complex evolutionary history
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New IQ-TREE-PoMo manuscript!
“Polymorphism-aware species trees with advanced mutation models, bootstrap and rate heterogeneity” by Dominik Schrempf, Bui Quang Minh, Arndt von Haeseler, and Carolin Kosiol. https://www.biorxiv.org/content/early/2018/12/01/483479
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Group leader Carolin Kosiol received Vetmeduni’s scientist of the year 2017/2018 award (category non-clinical research).
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WWTF Site Visit on the 13th November 2018. We meet at the Vetmeduni Vienna.