Genome-wide Molecular Dating

Zuckerkandl and Pauling showed 50 years ago that molecular sequences are ‘documents of evolutionary history’. The composition of the molecular sequences of organisms living today has been passed on from ancestors from long ago. Unused segments get lost, new parts are added and small changes occur because replication is not error free. Whatever modifications have happened, they will have left traces in the molecular sequences.

In the advent of next generation sequencing technologies we have thousands of genomes available, however, we lack methods for genome-wide molecular dating.  In this project, we will develop novel methods which will model not only mutations but also processes such as gene duplication, loss and transfer. We will also consider variation within species and devise methods that allow to use the genome-wide DNA sequences of multiple individuals per species to perform molecular dating.

  • Lynette Mikula started her PhD. Welcome to the team!

  • Our new manuscript is posted on bioRxiv!

  • Talk at SMBE Yokohama

     Carolin is giving a talk “Genome-wide estimation of the evolutionary history of six baboon species with polymorphism-aware phylogenetic models” at the SMBE2018, Symposium SY24, Room 302 at Thu 9th July 12:30-15:30. Check it out if you’re there!

  • Symposium at Evolution 2018 conference

    We are co-organizing the Symposium S31 “New approaches to phylogenomics” at the Evolution 2018 conference ( in Montpellier. Do come along if you’re there.  

  • Meeting in Budapest

    Carolin and Rui are visiting Gergely’s group including and Dominik Schrempf in Budapest today.

  • Congrats Dominik!

    Alumni Dominik Schrempf graduated “sub auspiciis praesidentis rei publicae”, Austria’s highest possible honor for graduates who have excelled throughout their education and studies.